Inhibition Of Cell Proliferation Through R.i.p. Of Creb3l1
Bray Denard
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Inhibition Of Cell Proliferation Through R.i.p. Of Creb3l1

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Inhibition of Cell Proliferation through Regulated Intramembrane Proteolysis of CREB3L1 guides the reader though the discovery of CREB3L1 as a membrane-bound transcription factor that prevents the proliferation of virus-infected cells. Upon activation, CREB3L1 is found to block the proliferation of cells infected with diverse DNA and RNA viruses, including murine gamma-herpesvirus 68, HCV, West Nile virus, and Sendai virus. The reader is then lead through the discovery that doxorubicin, a widely used anti-cancer drug, requires CREB3L1 to perform the anti-proliferative function utilized in canc...