Impact of low replication stress on normal and cancer cells
Lilas Courtot
Broschiertes Buch

Impact of low replication stress on normal and cancer cells

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DNA replication is very well orchestrated in mammalian cells thanks to a tight regulation of the temporal order of replication origin activation, called replication timing (RT). The RT is very robust and cell type specific. Upon low replication stress, replication forks progress slower and some fragile regions can undergo replication delay leading to DNA damage and genetic instability, a common marker of cancers. Except for these fragile regions, the direct impact of low replication stress on the RT of the whole genome has not been explored yet. In this thesis, I analyzed and compared the repl...