Identifying Genes That Encode APP Metabolism Modulators
Can Zhang
Broschiertes Buch

Identifying Genes That Encode APP Metabolism Modulators

A novel approach in functional genomics to gain insight into the pathogenesis of Alzheimer's disease

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Alzheimer's disease (AD) is a devastating neurodegenerative disease with complex and strong genetic inheritance. The central pathological event in AD is believed to be the regulated intramembrane proteolysis of the amyloid-beta precursor protein (APP), which generates accumulable amyloid-beta peptide and the APP intracellular domain (AICD). The genetic cause of AD is not fully identified, and up to 70% of the heritability of AD is unknown. In this "translational" study, we hijacked the transcriptional activation property of the AICD fragment and constructed a functional assay to discover novel...