Hyperimmunized Plasma as a Treatment for Horses with Acute Diarrhea
A prospective, blinded clinical trial
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This book includes a review of the pathophysiology of acute colitis in the adult horse and discussion of the more common etiologies for this condition and treatment options available to the equine clinician. The aim of the clinical study performed and documented was to evaluate the use of a hyperimmunized plasma containing high concentration of antibodies against Clostridium difficile, Clostridium perfringens and Salmonella sp in a referral population of equine colitis cases.Forty two horses were enrolled and 38 horses completed the study. At study admission clinical and clinicopathological pa...
This book includes a review of the pathophysiology
of acute colitis in the adult horse and discussion
of the more common etiologies for this condition and
treatment options available to the equine clinician.
The aim of the clinical study performed and
documented was to evaluate the use of a
hyperimmunized plasma containing high concentration
of antibodies against Clostridium difficile,
Clostridium perfringens and Salmonella sp in a
referral population of equine colitis cases.Forty
two horses were enrolled and 38 horses completed the
study. At study admission clinical and
clinicopathological parameters, other than fecal
frequency score were comparable between the groups.
Fecal frequency score was significantly different
between the treatment groups (p=0.003). The mean
duration of diarrhea was 40.7±9.8 hours (mean ±SEM),
119.2±56.1 hours and 72.0±24.5 hours for the
hyperimmunized plasma, normal plasma and control
groups respectively. This data confirms the
hyperimmunized plasma used in this study decreased
the time to resolution of diarrhea.
of acute colitis in the adult horse and discussion
of the more common etiologies for this condition and
treatment options available to the equine clinician.
The aim of the clinical study performed and
documented was to evaluate the use of a
hyperimmunized plasma containing high concentration
of antibodies against Clostridium difficile,
Clostridium perfringens and Salmonella sp in a
referral population of equine colitis cases.Forty
two horses were enrolled and 38 horses completed the
study. At study admission clinical and
clinicopathological parameters, other than fecal
frequency score were comparable between the groups.
Fecal frequency score was significantly different
between the treatment groups (p=0.003). The mean
duration of diarrhea was 40.7±9.8 hours (mean ±SEM),
119.2±56.1 hours and 72.0±24.5 hours for the
hyperimmunized plasma, normal plasma and control
groups respectively. This data confirms the
hyperimmunized plasma used in this study decreased
the time to resolution of diarrhea.
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