Human nasal primary cell cultures for peptide delivery studies
Hoang Vu Dang
Broschiertes Buch

Human nasal primary cell cultures for peptide delivery studies

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Many proteins and peptides possess biological activity that makes them highly specific and effective therapeutic agents. For the treatment of chronic diseases or disorders (e.g. diabetes, cancer, osteoporosis, etc), however, they cannot be orally administered due to a rapid hydrolysis of the peptide bonds by digestive proteases. This work was done to explore the nasal route as a promising alternative to parenteral injections for systemic delivery of proteins and peptides due to its high vascularity of the mucosa, large surface area, avoidance of first-pass metabolism, ease of drug administrati...