HPTLC METHOD

HPTLC METHOD

DEVELOPMENT AND VALIDATION OF VIBEGRON

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A stability-indicating high-performance thin-layer chromatography (HPTLC) method was developed and validated for determination of Vibegron. Optimization of conditions for the spectro densitometric procedure was reached by eluting HPTLC pre-coated silica gel aluminium plates in horizontal chamber. The solvent system consisted of Acetone. This system was found to give compact, dense and typical peak for Vibegron. Densitometric analysis of the drug was carried out in the reflectance mode at 254 nm by using a computer controlled densitometric scanner. The calibration curve Vibegron was linear in t...