HNO ADDUCTS OF HORSE MYOGLOBIN AND HUMAN HEMOGLOBIN
Generation, Reactivity, Reaction Rates...
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The first chapter is a summary of recent publications about the effect of HNO in the cardiovascular system, detection of HNO in vitro, and physiological reactivity of HNO. The second chapter provides synthetic details of a newly developed method of a synthesis of HNO-Mb of high purity ( 95%). The transient absorbance studies of HNO-Mb revealed completely different results than that of other myoglobin adducts such as MbO2 and NO-Mb. Formation of the Mb-Fe(III)/HNO- geminate pair was confirmed by analyses of transient absorbance spectra at 395 nm. In the third chapter rate constants of the react...
The first chapter is a summary of recent
publications about the effect of HNO in the
cardiovascular system, detection of HNO in vitro,
and physiological reactivity of HNO. The second
chapter provides synthetic details of a newly
developed method of a synthesis of HNO-Mb of high
purity ( 95%). The transient absorbance studies of
HNO-Mb revealed completely different results than
that of other myoglobin adducts such as MbO2 and NO-
Mb. Formation of the Mb-Fe(III)/HNO- geminate pair
was confirmed by analyses of transient absorbance
spectra at 395 nm. In the third chapter rate
constants of the reaction of HNO with Mb-Fe(II), Mb-
Fe(III), HNO-Mb, and HNO-Mb with oxygen and
nitric oxide were determined using the
computational software React for Windows. In
addition to the computational method, a direct
method of comparison of the rates of the reaction
of HNO with proteins was developed. In the last
chapter synthesis of HNO adduct of hemoglobin is
reported. UV-vis, EPR, and 1H NMR spectroscopic
techniques were used to identify and differentiate
the hydride peaks of HNO subunits of hemoglobin.
publications about the effect of HNO in the
cardiovascular system, detection of HNO in vitro,
and physiological reactivity of HNO. The second
chapter provides synthetic details of a newly
developed method of a synthesis of HNO-Mb of high
purity ( 95%). The transient absorbance studies of
HNO-Mb revealed completely different results than
that of other myoglobin adducts such as MbO2 and NO-
Mb. Formation of the Mb-Fe(III)/HNO- geminate pair
was confirmed by analyses of transient absorbance
spectra at 395 nm. In the third chapter rate
constants of the reaction of HNO with Mb-Fe(II), Mb-
Fe(III), HNO-Mb, and HNO-Mb with oxygen and
nitric oxide were determined using the
computational software React for Windows. In
addition to the computational method, a direct
method of comparison of the rates of the reaction
of HNO with proteins was developed. In the last
chapter synthesis of HNO adduct of hemoglobin is
reported. UV-vis, EPR, and 1H NMR spectroscopic
techniques were used to identify and differentiate
the hydride peaks of HNO subunits of hemoglobin.
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