HLA Expression in Leukemia
Durjoy Majumder
Broschiertes Buch

HLA Expression in Leukemia

Status, Regulation & Therapeutic Implications of HLA Expression in Leukemia

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Classical HLA class I (class Ia) downregulation may be the cause of immune escape mechanism by the cancer cells and is well documented in different cancers. Recently it is shown that in leukemia there is a locus specific HLA class Ia downregulation both at the antigenic and transcriptional level. As, so far, no mutation is recorded in HLA genes; so the reason may lies at the expression of different transcription factors (TRFs) that regulate its expression. Reports suggest that there is an alteration of the constitutive region binding TRFs of the HLA promoter in leukemia. Though there is upregu...