HLA-A*3101 Genetic Polymorphism influencing the Epilepsy treatment

HLA-A*3101 Genetic Polymorphism influencing the Epilepsy treatment

Based on a clinical-genetic study in patients with Generalized Tonic Clonic Epilepsy

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Human leukocyte antigens (HLA) refer to locus of genes encoding proteins present on the surface of white blood cells. They have important role in transplant rejections, Autoimmune disorders, HIV, Cancer and Cutaneous adverse drug reactions (CADRs). CADRs are one of the commonest adverse events in patients taking antiepileptic drugs (AEDs) which often lead to drug discontinuation. The association of HLA, particularly HLA-A 3101 with CADRs and epilepsy has made us conduct a clinical-genetic study in epileptic patients with the objective of finding the prevalence of HLA-A 3101 in comparison with ...