Ilona Diana Majella Wehl
Broschiertes Buch

High-throughput screening and evaluation of combinatorial cell penetrating peptoid libraries to identify organelle- and organ-specific drug delivery molecules

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Drug delivery systems can increase the pharmacokinetic and pharmacodynamic properties of various therapeutic agents. These systems can ensure a controlled release, improve the specificity of drugs to the target tissue, and therefore decrease side effects to the healthy surrounding tissue. In this work cell penetrating peptoids, which mimic the structure of peptides but exhibit increased stability, were investigated as organelle- and organ-specific carrier molecules. Several fluorescently labelled peptoid libraries, differing for example in length and side-chain composition, were synthesized an...