Hepatitis B Virus, Overview, Novel Genotypes And Subtypes
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Hepatitis B virus is a serious global public health problem. Severely cases of HBV can lead to chronic liver disease, including cirrhosis and hepatocellular carcinoma. Previously, HBV genotypes have been classified into 8 genotypes (A-H) and because of genome diversity is a hallmark of HBV allowed its classification into 10 genotypes from (A-J). The major classification of HBV subtype is classified into 4 subtypes or serotypes (adr, adw, ayr, and ayw). The clinical relevance of such genotype is yet unclear. However, because the HBV- induced disease is the resultant of virus-host interaction, t...
Hepatitis B virus is a serious global public health problem. Severely cases of HBV can lead to chronic liver disease, including cirrhosis and hepatocellular carcinoma. Previously, HBV genotypes have been classified into 8 genotypes (A-H) and because of genome diversity is a hallmark of HBV allowed its classification into 10 genotypes from (A-J). The major classification of HBV subtype is classified into 4 subtypes or serotypes (adr, adw, ayr, and ayw). The clinical relevance of such genotype is yet unclear. However, because the HBV- induced disease is the resultant of virus-host interaction, the disease characteristics may be influenced by the genotypes of the virus. Varieties methods have been used to detect HBV genotypes and subtypes including whole or partial genome sequencing, genotype-specific PCR amplification line prob assay, enzyme-linked immunoassay as well as other serological methods.
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