HDAC/HAT Function Assessment and Inhibitor Development
Broschiertes Buch

HDAC/HAT Function Assessment and Inhibitor Development

Methods and Protocols

Herausgegeben: Krämer, Oliver H.
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This fully updated edition provides a series of methods for how best to assess functions of histone deacetylases and acetyltransferases. The disease-relevance of dysregulated protein deacetylation by overexpressed or aberrantly activated histone deacetylases has spurred an intense search for novel and improved inhibitors of these enzymes, as reflected in this collection. Expert contributors explore the generation and evaluation of novel histone deacetylase inhibitors and new and improved techniques to assess acetylation-dependent molecular mechanisms in vitro and in vivo. Written for the highl...