Growth Factor VN Complexes Accelerate the Healing of Diabetic Ulcers
Anthony Noble
Broschiertes Buch

Growth Factor VN Complexes Accelerate the Healing of Diabetic Ulcers

Vitronectin _ Insulin Growth Factor - Insulin Growth Factor Binding Protein Complexes mediate cell migration and proliferation in skin from diabetics

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The findings outlined in this thesis show that VN:IGFBP:IGF-I complexes can elicit enhanced growth and migration in cells derived from skin from both normal and diabetic patients. Further, these responses are maintained in conditions found in the diabetic wound microenvironment, namely in the presence of high glucose and high calcium. Together these findings demonstrate the potential of the VN:IGFBP:IGF complexes as wound healing agents to treat wounds, especially diabetic ulcers. Such delayed healing wounds represent a significant burden to healthcare systems and are one of the primary condit...