Genetic, Haematologic and Inflammatory Markers in Prostate Cancer
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Prostate cancer (PCa) is a disease known for its marked international variation with significantly high incidence in the Western world. Diagnosis of the disease is made through physical examination, PSA assays and histopathological examination with Gleason score (Gold Standard) on biopsies taken from the prostate gland. In the search for better and more specific markers of PCa, recently an enzyme -Methylacyl CoA racemace (AMACR) was found to be consistently and extensively over-expressed in PCa. In Ghana, incidence of PCa is estimated at 7.3%, and diagnosis is based on digital rectal examinati...
Prostate cancer (PCa) is a disease known for its marked international variation with significantly high incidence in the Western world. Diagnosis of the disease is made through physical examination, PSA assays and histopathological examination with Gleason score (Gold Standard) on biopsies taken from the prostate gland. In the search for better and more specific markers of PCa, recently an enzyme -Methylacyl CoA racemace (AMACR) was found to be consistently and extensively over-expressed in PCa. In Ghana, incidence of PCa is estimated at 7.3%, and diagnosis is based on digital rectal examination, PSA assays and microscopical viewing of stained prostate biopsy sections with Gleason score. This study was designed to evaluate AMACR gene expression in tissue as well as blood samples and also to determine how selected inflammatory factors impact on the development of PCa among Ghanaian subjects. Seventy six (76) blood samples from 55 patients, (19 PCa and 36 BPH) and 21 healthy controls were taken for the study. Prostate biopsies were obtained from the cases, (PCa age range 52-89 years, mean 68.45 years and BPH age range 51-79 years, mean 66.35 years) were recruited for the study.
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