This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on Functional Neural Transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.
This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on Functional Neural Transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.
Dunnett is a behavioural neuroscientist who started a lifelong collaboration with the Björklund team in 1979 to explore the functional consequences of cell transplantation method in animal models of neurodegenerative disease, in particular involving cell replacement and repair of the basal ganglia. He has developed models and novel methods of motor and cognitive assessment to apply behavioural analysis not simply to assess functional efficacy of implanted cells, but as a tool to study the mechanisms of cell integration, circuit reconstruction and functional repair. In parallel his laboratory originated the first UK trial of cell transplantation in Huntington's disease, and provides the source of clinical grade cells for further ongoing trials in Parkinson's disease.
Inhaltsangabe
Preface
Stephen Dunnett and Anders Björklund
Transplantation in the Future
Fred H. Gage
Stroke
Neural Differentiation and Support of Neuroregeneration of Non-Neural Adult Stem Cells
Rojin Abraham and Catherine M. Verfaillie
Stem Cell Repair of Striatal Ischemia
Zaal Kokaia and Olle Lindvall
In-vivo Imaging of Cell Transplants in Experimental Ischemia
Joanna Adamczak and Mathias Hoehn
Bone Marrow Stem Cells in Experimental Stroke
Jeffery D. Kocsis andOsamu Honmou
Advantages and Challenges of Alternative Sources of Adult-Derived Stem Cells for Brain Repair in Stroke
Paul R. Sanberg, David J. Eve, Christopher Metcalf and Cesario V. Borlongan
Prospects for Stem Cell-Derived Therapy in Stroke
John D. Sinden, Indira Vishnubhatla and Keith W. Muir
Retinal and Cortical Repair
Generation of Retinal Cells from Pluripotent Stem Cells
Zi-Bing Jin and Masayo Takahashi
Generation of Cortical Neurons from Pluripotent Stem Cells
Pierre Vanderhaeghen
Spinal Cord Repair
A Glio-Centric View of Repair
Ying Li, Daqing Li and Geoffrey Raisman
Current Status of Myelin Replacement Therapies in Multiple Sclerosis
Jeffrey K. Huang and Robin J.M. Franklin
Stem Cell-Based Treatments for Spinal Cord Injury
Lindsey A. Wyatt and Hans S. Keirstead
The challenges of Long-Distance Axon Regeneration in the Injured CNS
Daniel J. Chew, James W. Fawcett and Melissa R. Andrews
Schwann Cell Transplantation: A Repair Strategy for Spinal Cord Injury?
Ryan R. Wiliams and Mary Bartlett Bunge
Generation of Motor Neurons from Pluripotent Stem Cells
Peter H. Chipman, Jeremy S. Toma and Victor F. Rafuse
Transplantation of Mesenchymal Stem Cells in ALS
Letizia Mazzini, Alessandro Vercelli, Ivana Ferrero, Marina Boido, Roberto Cantello and Franca Fagioli
