Functional analysis of Loqs and R2D2 in small RNA silencing pathways
Julia Verena Hartig
Broschiertes Buch

Functional analysis of Loqs and R2D2 in small RNA silencing pathways

The role of small double-stranded RNA binding domain proteins in the network of silencing pathways in Drosophila

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Small non-coding RNA-dependent gene silencing is a highly conserved mechanism found in fungi, plants and animals. Drosophila melanogaster is one of the best studied model-organisms for small RNA-dependent silencing. A variety of small RNA classes are involved in regulating a wide array of cellular processes ranging from development to cancer. Micro RNAs are genomically encoded and repress expression of endogenous genes. Exogenous small interfering RNAs serve to defend cells from viral infections and are widely used in artificial gene silencing by RNA interference. Piwi-interacting RNAs act to ...