From patch-clamp-spectroscopy towards patch-clamp-spectrometry
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From patch-clamp-spectroscopy towards patch-clamp-spectrometry

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Membrane ion channels operate in accordance with the main principles of coordination chemistry. Coordination number is known to determine the ion selectivity of the sodium and potassium channels. There are known both ligand-dependent and ligand-controlled ion channels operating within the supramolecular coordination fixation principles. The channel-forming ionophores form the structures which bind cations via coordination bonds leading to the conformational changes with the adjustment of the whole supramolecular architecture providing the ion channel selectivity. Such kind of non-covalent syst...