From Nose to Brain
Differentiation Factors and their Role in Olfactory Neurogenesis
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In the past decade the dogma that we are born with acertain number of nerve cells and that the brain isincapable of generating new neurons and renewingitself has been proven incorrect. There is a renewalprocess in the adult brain, called neurogenesis,facilitated by the presence of neuronal stem cells.The capacity of olfactory receptor neurons toregenerate from a pool of multipotent stem cellshighlights the olfactory neuroepithelium as animportant source of adult neuronal stem cells. Theolfactory stem cell has the undeniable advantage thatit can be easily used for autologous transplantationto a...
In the past decade the dogma that we are born with a
certain number of nerve cells and that the brain is
incapable of generating new neurons and renewing
itself has been proven incorrect. There is a renewal
process in the adult brain, called neurogenesis,
facilitated by the presence of neuronal stem cells.
The capacity of olfactory receptor neurons to
regenerate from a pool of multipotent stem cells
highlights the olfactory neuroepithelium as an
important source of adult neuronal stem cells. The
olfactory stem cell has the undeniable advantage that
it can be easily used for autologous transplantation
to avoid graft versus host reactions. Once this is
achieved new promising therapeutic venues for the
treatment of various neurological diseases can be put
into practice.
While the regenerative capacity of the olfactory
neuroepithelium has been well studied less is known
about the molecular events controlling adult
olfactory stem cell activity.
Therefore this book sheds light on the isolation and
characterisation of adult olfactory stem cells as
well as molecular mechanisms involved in olfactory
stem cell proliferation and differentiation.
certain number of nerve cells and that the brain is
incapable of generating new neurons and renewing
itself has been proven incorrect. There is a renewal
process in the adult brain, called neurogenesis,
facilitated by the presence of neuronal stem cells.
The capacity of olfactory receptor neurons to
regenerate from a pool of multipotent stem cells
highlights the olfactory neuroepithelium as an
important source of adult neuronal stem cells. The
olfactory stem cell has the undeniable advantage that
it can be easily used for autologous transplantation
to avoid graft versus host reactions. Once this is
achieved new promising therapeutic venues for the
treatment of various neurological diseases can be put
into practice.
While the regenerative capacity of the olfactory
neuroepithelium has been well studied less is known
about the molecular events controlling adult
olfactory stem cell activity.
Therefore this book sheds light on the isolation and
characterisation of adult olfactory stem cells as
well as molecular mechanisms involved in olfactory
stem cell proliferation and differentiation.
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