Formulation, Optimization and Evaluation of GRDDS
Atorvastatin Calcium Floating Microspheres
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The present study was an attempt to develop floating microspheres of Atorvastatin calcium using ethyl cellulose as polymer by non-aqueous solvent evaporation technique. FT-IR results shows there were no drug-polymer interaction. The influence of drug - polymer ratio and RPM on the physical characteristics of microspheres (size, drug loading and kinetic of release) were investigated In vitro release of Atorvastatin calcium from prepared microspheres was found to be satisfactory. Optimization was done. Among all the formulations, AT5 shows good drug release. From in-vitro drug release profile of...
The present study was an attempt to develop floating microspheres of Atorvastatin calcium using ethyl cellulose as polymer by non-aqueous solvent evaporation technique. FT-IR results shows there were no drug-polymer interaction. The influence of drug - polymer ratio and RPM on the physical characteristics of microspheres (size, drug loading and kinetic of release) were investigated In vitro release of Atorvastatin calcium from prepared microspheres was found to be satisfactory. Optimization was done. Among all the formulations, AT5 shows good drug release. From in-vitro drug release profile of all the formulations could be better expressed by higuchi model as they showed good linearity with "R" value. The optimized AT5 formulation was subjected to SEM analysis and accelerated stability studies by storing at various ICH storage conditions for 60 days. The samples were analyzed for its drug content and physical appearance at an interval of 15 days. It shows better storage at 25 C ± 2 C/60% RH. Thus, it can be concluded that AT5 formulation is shows better results and hence, Atorvastatin calcium as anti hyperlipoproteinamia can be successfully delivered as microspheres.
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