Formulation of Self Nano-Emulsifying Systems of Ezetimibe

Formulation of Self Nano-Emulsifying Systems of Ezetimibe

Effect of Lipidic Chain Length and HLB of Emulgents on In Vitro, In Situ Perfusion and In Vivo Pharmacodynamic Studies

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Oral route is preferred for the treatment of various diseases/disorders. However, the oral bioavailability of nearly 40% of newly discovered molecules is diminished due to various physicochemical and physiological barriers. The reasons of low and variable oral bioavailability include, high lipophilicity, restricted permeability, first pass metabolism in the gut and liver and efflux transporter systems. These problems, in turn, lead to high intra- and inter-subject variability and lack of dose proportionality. To overcome these drawbacks, various formulation strategies have been adopted. Howeve...