Formulation Development & Characterization of Matrix Tablet for CTDD
Colon Targeted Drug Delivery System
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The present investigation involves formulation development and characterization pg matrix tablet for colon targeted delivery with a view to extended the drug release in colonic segment. The extended release matrix tablet were formulated by using the combination of release retardant polymer. The polymer used were hydroxypropylmethylcellulose, eudragit L-30.D55. tablet were prepared by wet granulation technique using water. The granules were subjected to pre-compression evaluation such as bulk density, tap density, compressibility index, hausners ratio, particle size distribution and loss on dry...
The present investigation involves formulation development and characterization pg matrix tablet for colon targeted delivery with a view to extended the drug release in colonic segment. The extended release matrix tablet were formulated by using the combination of release retardant polymer. The polymer used were hydroxypropylmethylcellulose, eudragit L-30.D55. tablet were prepared by wet granulation technique using water. The granules were subjected to pre-compression evaluation such as bulk density, tap density, compressibility index, hausners ratio, particle size distribution and loss on drying. It was concluded that granules exhibited good compressibility and flow property. Prepared tablet were also evaluated for post-compression parameter like hardness, thickness, in-vitro dissolution, stability studies. Amongs the eight formulations F8 showed good results In-vitro dissolution studies were carried out for 12 hrs using 0.1 N HCl for 2 hrs and pH 7.2 for remaining 10 hrs. In-vitro dissolution studies showed that the formulation F8 releases 91.9 % of drug. Stability studies were carried out for formulayion F8 at 25 C/60% RH and 40 C/75% RH for 30 days.
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