Formulation and Evaluation of in-situ Gel for Glaucoma by -blocker
Sonam GandhiROHAN Barse
Broschiertes Buch

Formulation and Evaluation of in-situ Gel for Glaucoma by -blocker

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Spectrophotometric method was developed for the determination of BetaxololHCl in STF at 222.5 nm. FTIR spectrum of pure drug and drug-polymer mixture revealed no chemical interaction. Total fifteen batches of in-situ gelling system using gelrite and sodium alginate- HPMC E50LV for ion activated mechanism were prepared and passed through nylon membrane filter and terminally were sterilized by autoclaving at 121°C and15lb pressure for 20 min. Various in vitro parameters like gel retention time, clarity, pH, drug content, in vitro drug diffusion, test for sterility, viscosity determination were ...