Formulation & Evaluation Of Mucoadhesive Buccal Tablets Of Furosemide
Bhaskar Umarji
Broschiertes Buch

Formulation & Evaluation Of Mucoadhesive Buccal Tablets Of Furosemide

A Novel Approach For Enhancing Oral Bio Availability Of Furosemide For Treating Hypertensive Patients

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The objective of the study was to develop mucoadhesive buccal tablet of furosemide. Tablets of Furosemide were prepared by wet granulation method using mucoadhesive polymers like Carbopol 934P, Guar Gum, Chitosan and HEC in different ratios. Buccal tablets were evaluated by different methods for parameters such as thickness, hardness, weight uniformity, drug content uniformity, swelling index, surface pH, ex vivo mucoadhesive strength, ex vivo residence time, in vitro drug release, ex vivo drug permeation, stability studies. The tablets were evaluated for in vitro release in pH 6.8 phosphate b...