Floating, pulsatile, multiparticulate drug delivery system
Development & Evaluation of Floating Pulsatile, Multiparticulate Drug Delivery System Using Aceclofenac as a Model Drug
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The present study is aimed to develop floating, pulsatile, multiparticulate drug delivery system intended for chronopharmacotherapy in arthritis. Cross-linked beads were prepared by using low methoxylated pectin, sodium alginate, low methoxylated pectin + Sodium alginate and low methoxylated pectin + deacetylated gellan by acid- base reaction during ionotropic gelation. Beads were dried in oven at 500 degree Cenntigrate for 4hr. Aceclofenac was used as a model drug for encapsulation. Drug loaded multiparticulates were subjected to various characterization and evaluation parameters like entrapm...
The present study is aimed to develop floating, pulsatile, multiparticulate drug delivery system intended for chronopharmacotherapy in arthritis. Cross-linked beads were prepared by using low methoxylated pectin, sodium alginate, low methoxylated pectin + Sodium alginate and low methoxylated pectin + deacetylated gellan by acid- base reaction during ionotropic gelation. Beads were dried in oven at 500 degree Cenntigrate for 4hr. Aceclofenac was used as a model drug for encapsulation. Drug loaded multiparticulates were subjected to various characterization and evaluation parameters like entrapment efficiency, buoyancy study, surface topography.
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