Evolution, Modularity, and Dynamics of Gene Regulatory Networks
Versandkostenfrei!
Versandfertig in 6-10 Tagen
38,99 €
inkl. MwSt.
PAYBACK Punkte
19 °P sammeln!
This book studies the interplay between gene regulatory networks, phenotype and evolution via a combination of concept, theory and experiment. At the conceptual level, the author demonstrates thatgenes in regulatory networks group into surprisingly well-defined evolutionary modules with distinctive rates of evolution and conserved patterns of gene expression. At the theoretical level, the authordevelops a a novel probabilistic model for estimating the phylogeny of a pathway. Finally, the author analyses experimental data to reveal that genes sharing expression patterns (transcriptional modules...
This book studies the interplay between gene regulatory networks, phenotype and evolution via a combination of concept, theory and experiment. At the conceptual level, the author demonstrates thatgenes in regulatory networks group into surprisingly well-defined evolutionary modules with distinctive rates of evolution and conserved patterns of gene expression. At the theoretical level, the authordevelops a a novel probabilistic model for estimating the phylogeny of a pathway. Finally, the author analyses experimental data to reveal that genes sharing expression patterns (transcriptional modules) are not always evolutionarily conserved, but that genes sharing phylogenetic patterns (evolutionary modules) are typically co-expressed. These comparative approaches begin the attempt towardsa system-level understanding of how evolution is linked to the design and dynamics of regulatory networks, and how these networks functionacross timescales from microseconds to eons.
Andere Kunden interessierten sich für
