Evaluation of Peritoneal Cancer Index (PCI) in Advanced Ovarian Cancer
PCI evaluation in Epithelial Ovarian Cancer (EOC)
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Ovarian carcinoma is generally diagnosed at an advanced stage. Any gross peritoneal disease outside pelvis more than 2 cm in size is staged as FIGO stage IIIc. It encompasses a spectrum of disease from solitary tumor deposit anywhere in abdomen to diffuse peritoneal metastases resulting in a frozen abdomen. The prognosis of the patients across this spectrum vary widely. Therefore, there is a need to validate a score which can precisely prognosticate a patient with advanced ovarian carcinoma.The aim of surgery is to achieve optimal cytoreduction i.e. CCS 0/1. PCI is known to have a correlation ...
Ovarian carcinoma is generally diagnosed at an advanced stage. Any gross peritoneal disease outside pelvis more than 2 cm in size is staged as FIGO stage IIIc. It encompasses a spectrum of disease from solitary tumor deposit anywhere in abdomen to diffuse peritoneal metastases resulting in a frozen abdomen. The prognosis of the patients across this spectrum vary widely. Therefore, there is a need to validate a score which can precisely prognosticate a patient with advanced ovarian carcinoma.The aim of surgery is to achieve optimal cytoreduction i.e. CCS 0/1. PCI is known to have a correlation with CCS. However, PCI is calculated intraoperatively and therefore it cannot be used to predict optimal cytoreduction before conducting surgery itself. Contrast enhanced CT (CECT) scan is done at most centers before CRS. Multiple models have been evaluated to predict optimality of cytoreduction based on radiological and clinical factors.These studies have ascertained that CT-PCI grossly underestimates the lesion size in individual region as well as the overall score. We strive to examine this in the Indian population in our study.
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