Evaluation of MDA, HbA1c & SOD levels in type 2 Diabetic Retinopathy
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Diabetes mellitus comprises a group of metabolic disorders that share the common phenotype of hyperglycemia, association with the biochemical alteration of glucose and lipid peroxidation. Abnormalities in metabolism, including elevated polyol pathway, increased nonenzymatic glycation, accumulation of AGEs, uncontrolled oxidative stress, protein kinase C activity (PKC) and the expression of vascular endothelial growth factor (VEGF) result from glucose dysmetabolism and evidently also, contribute to the development of retinopathy. The aim of this study was to analyze and correlate determine the ...
Diabetes mellitus comprises a group of metabolic disorders that share the common phenotype of hyperglycemia, association with the biochemical alteration of glucose and lipid peroxidation. Abnormalities in metabolism, including elevated polyol pathway, increased nonenzymatic glycation, accumulation of AGEs, uncontrolled oxidative stress, protein kinase C activity (PKC) and the expression of vascular endothelial growth factor (VEGF) result from glucose dysmetabolism and evidently also, contribute to the development of retinopathy. The aim of this study was to analyze and correlate determine the levels of Malondialdehyde and Superoxide dismutase in patients of Type 2 diabetes mellitus with and without retinopathy. Concluded this study indicates the MDA and HbA1c level increase while there is a decrease SOD level, leading to oxidative stress in diabetic complications. Oxidative stress in diabetes mellitus, increasing over time may play a role in the pathogenesis of diabetic retinopathy. This fact is to be kept in mind when planning strategies for prevention of antioxidant vitamins (C, E) supplementation will produce a beneficial effect in complications of diabetes mellitus.
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