Evaluation of Antiulcer Activity of the Leaf of Osyris quadripartita

Evaluation of Antiulcer Activity of the Leaf of Osyris quadripartita

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Objective: To evaluate the antiulcer activity of the leaf extract of Osyris Quadripartita ( OQ) in albino wistar rats. Methods: The 80% methanolic extract of OQ leaves was subjected to acute toxicity test and phythochemical analysis. The extract's anti-ulcer activity were studied using the pylorus ligation and ethanol induced ulcer model both for dose dependent (100, 200, 400mg/kg) and time dependent (200mg/kg for 10 & 20 days) studies. Volume, pH, total acidity, ulcer score and ulcer index were determined for pylorus ligation induced ulcer model and ranitidine 50mg/kg (R50) was used as a stan...