Epilepsy: Novel GABA modulating agents and GABAergic imbalance in CNS

Epilepsy: Novel GABA modulating agents and GABAergic imbalance in CNS

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An imbalance between inhibitory and excitatory systems of neurotransmission in the central nervous system systems results in the development of dramatic pathological shifts in the central nervous system; such disturbances are one of the important factors responsible for the development of epilepsy. Epilepsy, the second most common neurological condition is characterized by recurrent seizures of cerebral origin. Despite the optimal use of available antiepileptic drugs (AEDs), many patients with epilepsy fail to experience seizure control and others do so only at the expense of significant toxic...