Epigenetic Predictors of chemosensitivity of Colorectal Cancer
The role of Global and Gene Specific DNA methylation in the Fluoropyrimidine Sensitivity of Colorectal Cancer Patients
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The Epigenetic Keys to Therapeutics Effectiveness of Fluoropyrimidine Therapy in Colorectal Cancer. Global DNA methylation as 5- methyl cytosines could be considered as a prognostic determinant of treatment efficacy. The methylation and expression of cycloxygenase and fluoropyrimidine metabolizing genes exhibited a clinical significance for individualized treatment. The Molecular Follow- Up along with the Clinicopathological Follow- Up is crucial for best management of colorectal cancer.
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