Enantiomeric separation of Valganciclovir by HPLC and LC/MS methods

Enantiomeric separation of Valganciclovir by HPLC and LC/MS methods

HPLC and LC/MS analysis of racemic drug

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Chiral separations occupy an important sector of HPLC-type analyses since many bioorganic molecules, as well as many pharmaceutical drugs, are chiral.However, the selection of a column in chiral separation and the development of a successful HPLC procedure remain a rather difficult subject. The differences in the interaction forces between enantiomers are typically small, and specific phases are more suitable than others for a specific separation.he selection of a chiral column for developing a separation is typically based on manufacturer recommendations. The selection of a chiral column for ...