Effect of E65 and E70 splice isoforms on electrophysiological properties of Kv10.1

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Project Report from the year 2013 in the subject Biology - Diseases, Health, Nutrition, grade: 1.3, University of Göttingen (Max Plank Institute for Experimental Medicine), language: English, abstract: Kv10.1, the voltage-gated non-inactivating delayed rectifier potassium channel, is overexpressed in variety of cancer cells and is involved in oncogenesis and tumor progression. Its splice variants E65 and E70, which were discovered in melanoma cell lines, have no conducting abilities but may physically interact with Kv10.1 and thereby regulate its function. Here, we investigated possible influ...