Broschiertes Buch

(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate

Non-mevalonate pathway, Isopentenyl pyrophosphate, Dimethylallyl pyrophosphate, Mycobacterium tuberculosis

Herausgegeben: Angelus, Jerold

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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. (E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP or HMB-PP) is an intermediate of the non-mevalonate pathway of isoprenoid biosynthesis. The enzyme HMB-PP synthase (GcpE, IspG) catalyzes the conversion of 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate (MEcPP) into HMB-PP, and HMB-PP is then converted further to isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) by HMB-PP reductase (LytB, IspH).