Broschiertes Buch

Drug Metabolism and Transport

Molecular Methods and Mechanisms

Herausgegeben: Lash, Lawrence H.

Beschreibung

A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.

Produktdetails

• Methods in Pharmacology and Toxicology
• Verlag: Humana / Humana Press / Springer, Berlin
• Artikelnr. des Verlages: 978-1-61737-494-4
• Seitenzahl: 388
• Erscheinungstermin: 9. November 2010
• Englisch
• Abmessung: 229mm x 152mm x 23mm
• Gewicht: 578g
• ISBN-13: 9781617374944
• ISBN-10: 1617374946
• Artikelnr.: 32211879

Rezensionen

"With the diverse subject matter and the wealth of information on techniques and research strategies there is likely to be something in this book to interest those from PhD students to more experienced researchers." -Newsletter of the British Toxicological Society