Drug Derivatization for Enhancement of Half-Life
Gupta Vivek
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Drug Derivatization for Enhancement of Half-Life

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Some of the drugs are having very short half-life, to compensate this problem it is common practice to increase the dosage, frequency or prolongation of administration of drug to maintain effective therapeutic concentration in patient. In this study a drug delivery scaffold was designed and synthesized based on polyethylene glycol (PEG)- ethylene diamine tetra acetic acid (EDTA) based poly(amidoamine) (PAMAM) star polymer (with 16 primary amine group on surface). Cloxacillin, Cephalexin and Ciprofloxacin were used as a model drugs having short half life to conjugate with PEGylated dendrimer. T...