Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease
Lazaros C. Triarhou
Broschiertes Buch

Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease

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Parkinson's disease, a degenerative brain disorder, affects an estimated 0.25-0.50% of the population. Symptoms result from neuronal degeneration in the nigrostriatal dopaminergic pathway and include tremor, rigidity and gradual slow ness of spontaneous movement. The cause of Parkinson's disease is only partially understood; both environmental factors and a genetic predisposition have been im plicated in its etiopathogenesis. Neural transplantation is being used experimentally for providing an alternative biological source of dopamine both in animal studies and in experimental clinical trials....