DNA-binding aromatic drug molecules
Maxim Evstigneev
Broschiertes Buch

DNA-binding aromatic drug molecules

Physico-chemical interactions and their biological roles

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Aromatic molecules have been widely utilized in medicine as components of therapeutic drugs effective against various diseases. Of utmost importance now is the use of aromatic drugs in combination (combinational therapy), which leads to synergistic improvement of the chemotherapeutic index compared to when used alone (monotherapy). In the majority of cases the mechanisms of biological synergy are unknown or not explained at the cellular level. This review focuses on the biological role of direct intermolecular interaction of DNA-binding aromatic drug molecules, including their self-association...