Distribution and Phenotype of Proliferating Cells in the Forebrain of Adult Macaque Monkeys after Transient Global Cerebral Ischemia
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1 Introduction.-.1 Studies on cell proliferation in adult primate brain.- 1.2 Methodological considerations in detecting cell proliferation.- 1.3 Cell proliferation in rodent brain after ischemia.- 1.4 Global cerebral ischemia in primates.- 2 Materials and Methods.- 2.1 Animal subjects.- 2.2 Bromodeoxyuridine infusion protocol.- 2.3 Tissue processing.- 2.4 Immunohistochemistry.- 2.5 Detection of DNA damage and degenerating cells.- 2.6 Electron microscopy.- 2.7 Image acquisition and analysis.- 2.8 Statistical analysis.- 3 Results.- 3.1 Hippocampal formation.- 3.1.1 Dentate gyrus.- 3.1.2 Cornu A...
1 Introduction.-.1 Studies on cell proliferation in adult primate brain.- 1.2 Methodological considerations in detecting cell proliferation.- 1.3 Cell proliferation in rodent brain after ischemia.- 1.4 Global cerebral ischemia in primates.- 2 Materials and Methods.- 2.1 Animal subjects.- 2.2 Bromodeoxyuridine infusion protocol.- 2.3 Tissue processing.- 2.4 Immunohistochemistry.- 2.5 Detection of DNA damage and degenerating cells.- 2.6 Electron microscopy.- 2.7 Image acquisition and analysis.- 2.8 Statistical analysis.- 3 Results.- 3.1 Hippocampal formation.- 3.1.1 Dentate gyrus.- 3.1.2 Cornu Ammonis.- 3.1.3 Subiculum.- 3.2 Subventricular zone of the inferior horn of the lateral ventricle (SVZi).- 3.3 Temporal lobe.- 3.3.1 Parahippocampal region.- 3.3.2 Temporal neocortex.- 3.4 Subventricular zone of the anterior horn of the lateral ventricle (SVZa).- 3.5 Rostral migratory stream and olfactory bulb.- 3.6 Frontal neocortex and striatum.- 4 Discussion.- 4.1 BrdU as a proliferation marker.- 4.2 Effects of ischemia on cell proliferation and differentiation.- 4.3 Sustained progenitor cell existence in germinative zones.- 4.4 Implications of monkey findings for therapies in humans.- 5 Summary.- References.- Subject Index.
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