DEVELOPMENT OF FENOPROFEN CALCIUM TABLETS FOR COLON TARGETING

DEVELOPMENT OF FENOPROFEN CALCIUM TABLETS FOR COLON TARGETING

FENOPROFEN CALCIUM TABLETS FOR COLON TARGETING

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Objective: The objective of the present investigation was to development of enteric coated tablet of fenoprofen calcium. Methods: The 32factorial design was used to preparation of compression-coated with a mixture of time dependent hydrophilic swellable polymer hydropropylcellulose (HPC), time released polymer Ethyl cellulose (EC) and pH responsive soluble polymer Instacoat EN Super II. The developed formulations were characterized for angle of repose, density, carr's index of powder mixture and thickness, diameter, hardness, friability, weight variation, uniformity content, in vitro disintegr...