Development of an SNP application
Michael Martin Pieler
Broschiertes Buch

Development of an SNP application

Based on real-time high resolution melting analysis of surface immobilized nucleic acids

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The development of an real-time microarray-based single-nucleotide polymorphism (SNP) application is discussed in this book. The SNP discrimination is based on the real-time analysis, hybridization kinetics and melting analysis, of DNA attached to the microarray and DNA in solution. One of the major challenges of this real-time approach is the management of the huge amount of data generated by the measurements: the measurement data of approx. 1,100 spots is loaded into a self-designed MATLAB® program which fits the data, automatically generates diagrams of the kinetics and the melting process...