Development and Validation of Periodontal In situ Gel of Articaine

Development and Validation of Periodontal In situ Gel of Articaine

Formulation,Evaluation and Validation of in situ gel of Articaine as a drug delivery system for Periodontal Anesthesia

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Articaine hydrochloride, a water soluble local anesthetic, is administered by block/infiltration anesthesia during the treatment of periodontitis. The pain, associated with injection of local anesthetics, can be overcome by the use of in situ gel forming system of local anesthetics. The system is a low viscosity fluid at room temperature and rigid elastic gel at body temperature, undergoing in situ sol gel transition.The present work describes the formulation, characterization and preliminary drug release studies of muco-adhesive formulations containing articaine, polaxomer 407 as the thermore...