Design of Sustained Release Tablet Using Melt Granulating Techniques
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Aceclofenac can be successfully designed in tablets as sustained release formulation using melt granulation technique. The present study has demonstrated that stearic acid could be successfully employed as a meltable binder. It is worthy of mentioning that for controlling the release of poorly water-soluble drugs, the method is still advantageous.The prepared Aceclofenac compressed tablets were tested for weight variation, content uniformity, friability, tablet thickness and drug content and all the parameters were found to be within the Pharmacopoeial limits. In vitro drug dissolution tests w...
Aceclofenac can be successfully designed in tablets as sustained release formulation using melt granulation technique. The present study has demonstrated that stearic acid could be successfully employed as a meltable binder. It is worthy of mentioning that for controlling the release of poorly water-soluble drugs, the method is still advantageous.The prepared Aceclofenac compressed tablets were tested for weight variation, content uniformity, friability, tablet thickness and drug content and all the parameters were found to be within the Pharmacopoeial limits. In vitro drug dissolution tests were performed and dissolution profile of the selected batch was matched with that of standard release profile suggested by USP. Hence, the formulation was selected as optimized formulation. The tablets were further evaluated for studying the effect of storage temperature and pH on drug release. The release profiles show no significant difference in drug releases. This confirms the prepared tablets were robust.
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