Design of ¿-peptide foldamers by stereochemistry and topology
Istvan M. Mandity
Broschiertes Buch

Design of ¿-peptide foldamers by stereochemistry and topology

The effect of backbone and side-chain on 3D structure of artificial self-organizing systems

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Novel -peptidic secondary structures have been gained with five and six membered alicyclic side-chains. We analyzed various secondary structures of different foldameric and -peptidic structures as a function of the back-bone stereochemical pattern. The results showed that the homochiral and the alternating heterochiral systems do not cover all the possibilities to create periodic secondary structures. The absolute configurations can be regarded as the basic instruction set in the assembly language of the peptidic foldamer sequences, and an stereochemical patterning approach was established. We...