Annika Groschner
Broschiertes Buch

Design and Synthesis of Modified SNARE Proteins with Respect to the ¿¿SNAP/NSF Mediated Disassembly

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Soluble N-ethylmaleimide-sensitive attachment receptor (SNARE) proteins are the key players in membrane fusion. Localized in opposed membranes, they assemble via the SNARE motif in a stable four-helix bundle bringing the membranes close to each other and promoting membrane fusion by using the energy release during complex formation. SNARE complex assembly is regulated by several proteins. One of these, Complexin, is known to partially associate with the core complex, it may stabilize SNARE complex intermediates and unbinds upon calcium trigger. Nevertheless, the exact function of Complexin is ...