Design and Analysis of Clinical Trials with Time-to-Event Endpoints
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This resource provides a thorough presentation of the design, monitoring, analysis, and interpretation of clinical trials in which time-to-event is of critical interest. Incorporating the collaborations of truly world-class statisticians, it discusses the design and monitoring of Phase II and III clinical trials with time-to-event endpoints. The book presents parametric, semiparametric, categorical, and Bayesian inferential and descriptive methods for analyzing time-to-event endpoints and covers numerous clinical trial applications, including analgesic, antibiotic, antiviral, cancer and cardio...
This resource provides a thorough presentation of the design, monitoring, analysis, and interpretation of clinical trials in which time-to-event is of critical interest. Incorporating the collaborations of truly world-class statisticians, it discusses the design and monitoring of Phase II and III clinical trials with time-to-event endpoints. The book presents parametric, semiparametric, categorical, and Bayesian inferential and descriptive methods for analyzing time-to-event endpoints and covers numerous clinical trial applications, including analgesic, antibiotic, antiviral, cancer and cardiovascular prevention, optimal assignment of treatments, adverse events, and carcinogenicity.
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