Correlation of Hepcidin Level in Major Thalassemia

Correlation of Hepcidin Level in Major Thalassemia

Correlation of Hepcidin Level with Insulin Resistance and Endocrine Glands Function in Major Thalassemia

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Background. Hepcidin is a master regulator of iron metabolism that inhibits the transport of iron out of enterocytes and macrophages. Thalassemia major (TM) is associated with some of the endocrine disorders. However, studies have yet to be conducted on the correlation of hepcidin with hormone levels and insulin resistance (IR) in patients with TM.Objectives. In the present study, the correlation of hepcidin level with some endocrine and biochemical parameters was investigated to determine the factors that mainly affect hepcidin correlation in patients with thalassemia. These factors include h...