Consequences of altered poly(ADP-ribose) polymerase-1 expression
Tobias Eltze
Broschiertes Buch

Consequences of altered poly(ADP-ribose) polymerase-1 expression

Effects of altered PARP-1 expression

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Poly(ADP-ribosyl)ation is a posttranslational modification of cellular proteins mostly catalysed by poly(ADP-ribose) polymerase-1 (PARP-1) and to a lesser extent by PARP-2. The study aimed to explore the role of PARP-1 in DNA repair and cell death using in vitro as well as in vivo models and contributed to the potential use of a novel highly-selective PARP-1 inhibitor, which provides a valuable tool to dissect different roles of PARP-1 and PARP-2 in cellular functions. Overexpression of human PARP-1 (hPARP-1) in rodent cells resulted in an increased DNA repair capacity after X-irradiation, but...