Building from the perspective of reproductive and developmental biology, this book provides a timely and comprehensive overview of computational approaches in reproductive and developmental toxicology. It is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next section reviews the biological processes and endpoints involved in reproduction and development. The final and largest section summarizes protocols for evaluating biological…mehr
Building from the perspective of reproductive and developmental biology, this book provides a timely and comprehensive overview of computational approaches in reproductive and developmental toxicology. It is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next section reviews the biological processes and endpoints involved in reproduction and development. The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods.
Edited by Donald R. Mattison, National Institutes of Health, Bethesda, Maryland, USA, and Risk Sciences International, Ottawa, Ontario, Canada
Inhaltsangabe
INTRODUCTION. Introduction. Visions and Advancements for Meeting the Needs of Safety Assessment of Pharmaceutical and Industrial Chemicals. REACH and Environmental Chemicals.REPRODUCTION AND DEVELOPMENT: BIOLOGICAL PROCESSES AND ENDPOINTS. Female Reproductive Physiology. Maternal Recognition of Pregnancy. Early Embryo Development and Bipotential Gonad Formation. Assessing the Reproductive Health of Men with Occupational Exposures. REPRODUCTION AND DEVELOPMENT: BIOLOGICAL AND COMPUTATIONAL METHODS. Animal Study Protocols and Alternative Assays for the Assessment of Reproductive and Developmental Toxicity. US National Library of Medicine Resources for Computational Toxicology. Modeling Endocrine Regulation of the Menstrual Cycle Using Delay Differential Equations. Molecular Structural Characteristics That Influence Partitioning of Xenobiotics into Human Breast Milk. Approaches for Pediatric Developmental Drug-Induced Liver Injury. Adverse Outcome Pathways for Developmental Toxicity.
INTRODUCTION. Introduction. Visions and Advancements for Meeting the Needs of Safety Assessment of Pharmaceutical and Industrial Chemicals. REACH and Environmental Chemicals.REPRODUCTION AND DEVELOPMENT: BIOLOGICAL PROCESSES AND ENDPOINTS. Female Reproductive Physiology. Maternal Recognition of Pregnancy. Early Embryo Development and Bipotential Gonad Formation. Assessing the Reproductive Health of Men with Occupational Exposures. REPRODUCTION AND DEVELOPMENT: BIOLOGICAL AND COMPUTATIONAL METHODS. Animal Study Protocols and Alternative Assays for the Assessment of Reproductive and Developmental Toxicity. US National Library of Medicine Resources for Computational Toxicology. Modeling Endocrine Regulation of the Menstrual Cycle Using Delay Differential Equations. Molecular Structural Characteristics That Influence Partitioning of Xenobiotics into Human Breast Milk. Approaches for Pediatric Developmental Drug-Induced Liver Injury. Adverse Outcome Pathways for Developmental Toxicity.
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