Computational Approaches

Computational Approaches

A worm case study

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Systems biology seeks to integrate high-throughput biological studies to understand how biological systems function, by studying the relationships and interactions between various parts of a biological system. The metabolic networks, as a systemic cellular organization, can be reconstructed based on genomic information. The center- piece of this information is protein-protein interaction map of the studied organism. Signature content of proteins was utilized to reveal protein interactions upon a notion that when two proteins share signature in their primary structures, the two proteins are mor...