COMPACT KERNEL OF A METABOLIC FLUX BALANCE SOLUTION SPACE
Wynand S Verwoerd
Gebundenes Buch

COMPACT KERNEL OF A METABOLIC FLUX BALANCE SOLUTION SPACE

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This monograph offers a fundamentally new approach to facilitate the study of metabolic networks in cells. It aims to overcome the limitations of either just a single FBA solution, or an overwhelming number of extreme pathways in a realistic network. Instead it focusses on the FBA solution space and describes it in a simplified way by extracting just a bounded subspace: the Solution Space Kernel or SSK. This reduces the relevant number of flux space dimensions by orders of magnitude, and allows its location, size and shape to be characterised. It is a multi-stage process, requiring many new co...